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Listeriosis

P Kalis, J L Le Frock, W Smith

    The American Journal of the Medical Sciences
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Listeria monocytogenes infections, particularly meningitis, can occur with lymphoproliferative disorders. Early diagnosis and antibiotic therapy are crucial for recovery from this global health concern.

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    Area of Science:

    • Infectious Diseases
    • Neurology
    • Hematology

    Background:

    • Listeriosis, caused by Listeria monocytogenes, is a significant global health issue in humans and animals.
    • Human listeriosis epidemiology remains poorly understood, with animals and animal products as potential reservoirs.
    • Meningitis is the most frequent clinical presentation of human listeriosis.

    Observation:

    • This case series presents four patients with Listeria monocytogenes infection.
    • Three of the four patients had concurrent lymphoproliferative disorders.
    • Two patients presented with Listeria meningitis, highlighting its commonality.

    Findings:

    • Clinical differentiation of Listeria meningitis from other acute meningitis forms is challenging.
    • Definitive diagnosis relies on identifying Listeria monocytogenes in cerebrospinal fluid.

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  • Antibiotic treatment led to recovery in three out of the four patients.

    • Implications:

    • Early and accurate laboratory diagnosis of Listeria monocytogenes is critical for effective treatment.
    • Understanding the epidemiology is vital for controlling the spread of listeriosis.
    • This review synthesizes current knowledge on listeriosis history, diagnosis, and therapy.