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[The cornea and synthetic antimalarials]

A Jeddi1, N Ben Osman, F Daghfous

  • 1Institut Hédi Rais d'Ophtalmologie, Tunis, Tunisie.

Journal Francais D'Ophtalmologie
|January 1, 1994
PubMed
Summary
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Chloroquine (Nivaquine) can cause ocular toxicity, primarily affecting the cornea, ciliary body, and retina. While 73% of patients developed keratopathy, it does not contraindicate further antimalarial treatment, unlike retinopathy.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Context:

  • Antimalarial drugs, such as chloroquine (Nivaquine), are widely used but can cause ocular side effects.
  • Ocular toxicity is a significant concern, potentially affecting various parts of the eye.

Purpose:

  • To describe the clinical features and course of chloroquine-induced keratopathy.
  • To investigate the relationship between keratopathy and retinopathy in patients treated with chloroquine.
  • To determine if keratopathy is a contraindication for continued antimalarial therapy.

Summary:

  • Sixty patients treated with chloroquine (Nivaquine) were evaluated for ocular toxicity.
  • 73% of patients exhibited keratopathy, a condition affecting the cornea.
  • The study detailed the clinical presentation and progression of keratopathy and its association with retinopathy.

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Impact:

  • Keratopathy, unlike retinopathy, is not a contraindication for antimalarial treatment, allowing for continued therapy in affected patients.
  • Understanding the distinct clinical courses of keratopathy and retinopathy aids in managing antimalarial ocular toxicity.
  • This research provides crucial information for ophthalmologists and physicians managing patients on long-term antimalarial drugs.