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Transient localization of 5-HT1A receptors in human cerebellum during development
E del Olmo1, A Díaz, M Guirao-Piñeyro
1Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain.
Abstract:
The appearance and distribution of 5-HT1A receptors in the human cerebellum during the ontogenetic development was studied in samples from a group of fetal, neonatal and adult cases, by means of quantitative autoradiography and membrane binding. [3H]8-OH-DPAT was used as a ligand. High densities of 5-HT1A receptors were found during the fetal and neonatal stages over the whole cerebellar cortex, with a slight predominance in the external part, in a band which included the molecular layer. In contrast, the adult cerebellum was nearly devoid of such sites. This finding supports a role for 5-HT1A receptors in the regulation of development in the human cerebellum.