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Central noradrenergic reactivity to stress in Maudsley rat strains
M Buda1, J Lachuer, V Devauges
1INSERM U 171 and CNRS URA 1195, Laboratoire de Neurochimie Fonctionnelle, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.
Abstract:
Maudsley reactive (MR) and Maudsley nonreactive (MNRA) rats were submitted to a single session of acute 5-min immobilization stress and immediately sacrificed by decapitation. Subsequent neurochemical analysis revealed an elevation of 3,4-dihydroxyphenylacetic acid levels in the locus coeruleus and in the ventrolateral medulla, but not in the dorsomedial medulla, of rats of the two strains compared with nonstressed controls. This response was greater in the MR than in the MNRA group, suggesting a strain difference in the reactivity of the central noradrenergic cells to acute stress.