[Principal mechanisms of autoimmunity]
Related Experiment Video
Updated: Aug 22, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
1Laboratoire d'immunologie, Centre hospitalier universitaire, Brest.
Abstract:
T lymphocyte tolerance is achieved within the thymus (clonal deletion) and pursued in the peripheral organs (clonal anergy), whilst 'the B cell repertoire is skewed to favour low affinity autoantibodies. This tolerance may be bypassed through B cell polyclonal activation, autoantigen driving or major histocompatibility complex molecule engagement. Autoimmunity is perpetuated, due to control system deficiency, and leads to visceral complications. Autoantibodies and T lymphocytes may be pathogenic, as well as immune complexes.
More Related Videos
Related Concept Videos
What is the Immune System?
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology

