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The stem-loop structure of the cis-encapsidation signal is highly conserved in naturally occurring hepatitis B virus
T Laskus1, J Rakela, D H Persing
1Department of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Virology
|May 1, 1994
Abstract:
The region encoding the stem-loop structure of the HBV cis-encapsidation signal was sequenced in 87 patients with various forms of hepatitis. Altogether, 20 nucleotide substitutions were found; 15/20 were predicted to increase the stability of the stem-loop structure. Substitutions likely to decrease the stability of the cis-encapsidation signal were not observed.