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Related Experiment Videos

Neomycin metabolism in calves

P W Aschbacher1, V J Feil

  • 1Biosciences Research Laboratory, ARS, USDA, Fargo, ND 58105.

Journal of Animal Science
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Neomycin absorption in calves is significantly higher in younger animals and when administered orally via a bottle compared to older calves or capsules. Kidney tissue showed the highest neomycin concentration.

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Area of Science:

  • Veterinary Pharmacology
  • Animal Science
  • Drug Metabolism

Background:

  • Oral neomycin is used in calves, but its absorption and disposition are not fully understood.
  • Factors like age, diet, and administration method can influence drug absorption in young animals.

Purpose of the Study:

  • To determine the disposition of oral neomycin in calves.
  • To investigate the effects of age, diet, and administration method on neomycin absorption.

Main Methods:

  • Calves were administered a single oral dose of 14C-labeled neomycin.
  • 14C distribution in excreta and tissues was measured 96 hours post-dose.
  • Neomycin compounds were characterized using mass spectrometry and NMR spectroscopy.

Main Results:

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  • Younger calves (3-day-old) showed greater neomycin absorption (11.1%) than older calves (1.5%).
  • Administration via a nippled bottle resulted in higher absorption (2.13%) than capsules (0.5%) in ruminating calves.
  • Kidneys had the highest neomycin concentration (55 ppm), with neomycin being the major compound in kidneys and feces.

Conclusions:

  • Neomycin absorption in calves is age-dependent, with significantly higher absorption in younger animals.
  • The method of oral administration influences neomycin absorption, with liquid formulation via a bottle being more effective than capsules.
  • Neomycin is primarily concentrated in the kidneys and remains largely unmetabolized in calves.