[Comparative characterization of morphologic changes in animal brain after normo-, hypobaric hypoxic hypoxia and...

In three series of experiments on 16 randomly inbred adult male rats, specific features of morphological changes in the brain were studied 3 days following the tests of animals for high- or low-resistance to hypoxic hypoxia (HH) during hypobaric HH (Series I), normobaric HH (Series II), and hypobaric normoxia (Series III). The conventional testing was found to result in changes in the rat brain, which were caused both by HH and decompression. The more sparing procedure is testing animal during normobaric HH which eliminates the impact of decompression whose damaging action was pronounced in hypobaric normoxia. Thus, the sensitivity of rats to HH should be detected, by using the least brain-traumatizing modified procedure--normobaric HH.