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Significant species differences in local IGF-I and -II gene expression
1Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH Bethesda, MD 20892.
Comparison of renal and ovarian IGF system gene expression in the rat and human has shown that IGF-I mRNA is predominant in rat and IGF-II in human tissues, and that the two IGFs demonstrate different cellular patterns of expression in the homologous organs. IGF-I receptor gene expression, however, describes an apparently identical pattern in the tissues of both rat and human, suggesting that, although local sources and presumably regulation of IGF expression vary between the species, the ultimate functions served might be the same.
Comparison of renal and ovarian IGF system gene expression in the rat and human has shown that IGF-I mRNA is predominant in rat and IGF-II in human tissues, and that the two IGFs demonstrate different cellular patterns of expression in the homologous organs. IGF-I receptor gene expression, however, describes an apparently identical pattern in the tissues of both rat and human, suggesting that, although local sources and presumably regulation of IGF expression vary between the species, the ultimate functions served might be the same.