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Regulation of intracellular calcium in cardiac muscle
P H Backx1, W D Gao, M D Azan-Backx
1Department of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Advances in Experimental Medicine and Biology
|January 1, 1993
Abstract:
We have investigated the regulation of intracellular free calcium in heart muscle using the free acid form of the Ca2+ indicator fura-2 iontophoretically microinjected into rat cardiac trabeculae or ferret papillary muscles. This method shows great promise in elucidating a number of crucial questions in cardiac excitation-contraction coupling.