[Lipid peroxidation processes in the blood of patients during thoracic surgery]

Lipid peroxidation processes (malonic dialdehyde, parameters of induced Fe(2+)-chemiluminescence) have been studied in 22 patients operated on for diseases of the lungs and mediastinum and 15 patients subjected to heart surgery for ischemic disease. It has been shown that the severity of the disease depends on the activity of lipid peroxidation and the presence of a toxic product, malonic dialdehyde, in the blood plasma. The incidence and severity of postoperative complications were also higher in patients with intensive lipid peroxidation. The necessity of preventive therapy with antioxidants both in the pre- and postoperative periods has been substantiated.