Related Experiment Video
Updated: Aug 9, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Population genetics of the angiotensin-converting enzyme in Chinese
1Department of Pharmacology, National University of Singapore.
Abstract:
A genetic polymorphism exists for the angiotensin-converting enzyme (ACE) gene which accounts for 44% of the variance of circulating ACE activity in a normal Caucasian population. The presence or absence of a 250 bp fragment in intron 16 of the gene serves as a marker for this polymorphism. One hundred and eighty-nine normal Chinese subjects were genotyped and phenotyped for this ACE polymorphism. The frequencies of the deletion and insertion alleles among Chinese are 0.3 and 0.7 respectively, indicating a much higher prevalence of the insertion allele than had been reported among Caucasians.
Related Concept Videos
Incomplete Dominance
Single Nucleotide Polymorphisms-SNPs
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

