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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Deep vein thrombosis in end-stage renal disease
O Ifudu1, V B Delaney, R H Barth
1Health Science Center, State University of New York at Brooklyn.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 1, 1994
Summary
Patients with end-stage renal disease typically have bleeding risks due to platelet dysfunction. However, this study highlights rare cases where deep vein thrombosis occurred, suggesting overwhelming prothrombotic factors.
Area of Science:
- Nephrology
- Hematology
- Vascular Medicine
Background:
- End-stage renal disease (ESRD) is associated with acquired platelet dysfunction, characterized by reduced platelet adhesion and aggregation.
- This dysfunction typically results in prolonged bleeding times and a reduced tendency for thrombosis in ESRD patients.
Observation:
- Three patients with end-stage renal disease undergoing maintenance hemodialysis were observed to develop deep vein thrombosis (DVT).
- This presentation is unusual given the known bleeding diathesis in this patient population.
Findings:
- Despite the expected bleeding tendency in ESRD patients, these cases demonstrate that potent prothrombotic forces can override this protective mechanism.
- The occurrence of DVT in these patients suggests a complex interplay of factors contributing to a hypercoagulable state.
Implications:
- These findings challenge the assumption that deep vein thrombosis is exceedingly rare in all end-stage renal disease patients.
- Further research is warranted to identify specific risk factors and underlying mechanisms that predispose certain ESRD patients to thrombosis.
- Clinical vigilance for thrombotic events is crucial in end-stage renal disease patients, even those with known platelet dysfunction.
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