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Lp(a) lipoprotein: an overview

K Berg1

  • 1Institute of Medical Genetics, University of Oslo, Norway.

Chemistry and Physics of Lipids
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Lipoprotein(a) [Lp(a)] is a genetically determined lipoprotein linked to coronary heart disease. Lp(a) may bridge atherogenesis and thrombogenesis, suggesting its measurement is crucial for diagnosing heart disease.

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Area of Science:

  • Biochemistry
  • Genetics
  • Cardiovascular Medicine

Background:

  • Lipoprotein(a) [Lp(a)], identified in 1962, is a distinct serum lipoprotein.
  • Structurally, Lp(a) comprises a low-density lipoprotein (LDL) particle covalently linked to apolipoprotein(a) via a disulfide bridge.
  • The genetic determination of Lp(a) levels was initially proposed and later confirmed by linkage to the plasminogen gene.

Purpose of the Study:

  • To review the characteristics of Lp(a).
  • To highlight the association between Lp(a) and coronary heart disease (CHD).
  • To discuss the implications of Lp(a) in atherogenesis, thrombogenesis, longevity, and placental function.

Main Methods:

  • Literature review and synthesis of existing research on Lp(a).
  • Analysis of genetic linkage studies.

Related Experiment Videos

  • Examination of epidemiological data linking Lp(a) to cardiovascular disease.

    • Main Results:

    • Lp(a) levels are genetically determined, with the LPA gene linked to the plasminogen gene.
    • A strong association exists between elevated Lp(a) levels and increased risk of coronary heart disease, confirmed across numerous studies.
    • Lp(a) exhibits both atherogenic and thrombogenic properties, potentially linking these two processes.

    Conclusions:

    • Lp(a) plays a significant role in cardiovascular disease pathogenesis.
    • Moderate Lp(a) levels might be associated with longevity.
    • Measurement of Lp(a) is recommended in the diagnostic work-up for individuals with premature or familial coronary heart disease.