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Gallbladder visualization with In-111 labeled octreotide
Y Krausz1, N Shibley, R B De Jong
1Department of Nuclear Medicine, Hadassah University Hospital, Jerusalem, Israel.
Clinical Nuclear Medicine
|February 1, 1994
Summary
Avoid fasting abdominal scans with In-111 DTPA octreotide. Gallbladder uptake in somatostatin receptor imaging disappears after a meal, preventing false positives and negatives.
Area of Science:
- Nuclear Medicine
- Oncology Imaging
Background:
- Indium-111 DTPA octreotide offers advantages over Iodine-123 octreotide for somatostatin receptor imaging.
- Its renal clearance reduces interference compared to hepatobiliary clearance.
Purpose of the Study:
- To evaluate the impact of fasting on gallbladder visualization during In-111 DTPA octreotide imaging.
- To establish optimal imaging protocols to avoid misinterpretation of gallbladder uptake.
Main Methods:
- Administration of In-111 DTPA octreotide for somatostatin receptor scintigraphy.
- Comparison of imaging findings in fasting versus postprandial states.
Main Results:
- Distinct gallbladder visualization was observed in three patients during fasting.
- This gallbladder uptake resolved after a meal in all affected patients.
Conclusions:
- Abdominal scans using In-111 DTPA octreotide should not be performed in a fasting state.
- Repeating scans after a fatty meal can prevent false-positive and false-negative interpretations of gallbladder uptake.