[Nephrogenic mechanism of post-traumatic hemolysis]

The crush-syndrome model was introduced for experimental evaluation of the kidney-related mechanism of red cell destruction in an early posttraumatic period (1 day). Absolute and relative counts of the red cells, HCT were found reduced, while serum hemoglobin was on the increase in rats with crush syndrome against the controls and rats subjected to trauma and nephrectomy. Renal perfusion in situ with syngeneic blood brought about a decline in rat erythrocyte functional performance and a rise in the level of free hemoglobin. The findings support participation of the local nephrogenic hemolytic component in pathogenesis of early posttraumatic anemia.