Related Experiment Video
Updated: Aug 15, 2026
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
Published on: May 2, 2017
[Further study of the pathological process induced in monkeys by LPV oncornavirus]
Abstract:
Experiments were performed on pathogenicity of LPV oncornavirus and Mason-Pfizer-like virus for monkeys Macaca mulatta. The mixture of culture fluid and cell homogenate ultrafiltrates of virus-producing T-9 cell line was used as a source of LPV virus. The same materials derived from HEp-2 continuous cell line served as a source of Mason-Pfizer-like virus. As a control monkeys were inoculated with ultrafiltrates from human diploid cells. The clinical and pathomorphological analysis of experimental results leads to the conclusion, that only LPV virus induced different forms of haemacytoblastosis in monkeys that confirms our previous observations.
Insights
The LPV oncornavirus caused haemacytoblastosis in rhesus monkeys (Macaca mulatta). Mason-Pfizer-like virus did not induce this effect, confirming prior findings on LPV pathogenicity.
Area of Science:
- Virology
- Oncology
- Primate research
Context:
- Investigating the pathogenicity of oncornaviruses in non-human primates is crucial for understanding viral disease mechanisms.
- The Mason-Pfizer virus and LPV are significant oncornaviruses with potential implications for primate health.
Purpose:
- To determine the pathogenicity of LPV oncornavirus and Mason-Pfizer-like virus in Macaca mulatta.
- To compare the effects of these two viruses in a primate model.
- To validate previous observations regarding LPV's effects.
Summary:
- Experiments utilized ultrafiltrates from virus-producing T-9 and HEp-2 cell lines as sources for LPV and Mason-Pfizer-like virus, respectively.
- Rhesus monkeys were inoculated with these viral sources and control ultrafiltrates from human diploid cells.
- Clinical and pathomorphological analyses revealed that only the LPV oncornavirus induced various forms of haemacytoblastosis.
Impact:
- This study confirms LPV's ability to induce haemacytoblastosis in rhesus monkeys.
- Findings contribute to the understanding of oncornavirus pathogenicity and host-specific responses.
- Results support the use of Macaca mulatta as a model for studying LPV-induced hematological changes.
More Related Videos
06:02Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019