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[Susceptibility to antibiotics and biochemical activity of strains of Acinetobacter sp. isolated from various
1Katedra i Zakład Mikrobiologii AM, Bydgoszczy.
Abstract:
The study was performed on 576 Acinetobacter strains isolated from clinical material, objects from hospital, environment, soil, water and from animals. Applying API 20NE system identification was following: A. baumanii (61.1%), A. junii (19.4%), A. haemolyticus (4.3%), A. lwoffii (3.3%), A. johnsonii (0.52%) and not belonging to above genus strains (11.3%). Over 47% strains of Acinetobacter were isolated from clinical material as the only bacteria (mainly from samples received from intensive care units and surgical and urological wards). Out of 23 antibiotics and antimicrobials used for investigation of 535 strains of Acinetobacter, most active were imipenem (99%) of susceptible strains, ofloxacin and ciprofloxacin (95%) and netilmicin (88%). Multiple resistant strains were isolated more frequently from hospital environment than from other sources--these were mostly A. baumanii and A. junii.
Insights
This study identified Acinetobacter strains from various sources, finding Acinetobacter baumanii most common. Imipenem, ofloxacin, and ciprofloxacin showed high activity against susceptible strains.
Area of Science:
- Microbiology
- Antimicrobial Resistance
Context:
- Acinetobacter species are significant opportunistic pathogens, frequently isolated from clinical settings.
- This study investigated the prevalence and antimicrobial susceptibility of Acinetobacter strains from diverse sources.
Purpose:
- To identify Acinetobacter species from clinical and environmental samples.
- To determine the antimicrobial susceptibility patterns of the isolated Acinetobacter strains.
Summary:
- 576 Acinetobacter strains were identified using the API 20NE system, with Acinetobacter baumanii (61.1%) being the predominant species.
- Over 47% of Acinetobacter strains were isolated from clinical materials, particularly from intensive care units and surgical/urological wards.
- Imipenem (99% susceptibility), ofloxacin (95%), and ciprofloxacin (95%) were the most effective antimicrobials against susceptible strains. Multiple drug-resistant strains were more prevalent in hospital environments, primarily A. baumanii and A. junii.
Impact:
- Provides crucial data on the prevalence and antibiotic resistance profiles of Acinetobacter species in a specific region.
- Highlights the effectiveness of certain antibiotics, guiding empirical treatment strategies for Acinetobacter infections.
- Identifies hospital environments as reservoirs for multidrug-resistant Acinetobacter, emphasizing the need for enhanced infection control measures.