[Ultrastructural changes in ovarian tumor cancer cells under the influence of preoperative chemotherapy]

Studies of ultrastructural changes in cancerous cells of tumours of the ovaries in patients who had undergone preoperative chemotherapy, and the ultrastructural organization of cancerous cells of the overies in patients who had received no such treatment were carried out. Comparisons of the data obtained were made. It is established that preoperative chemotherapy brought about changes both in the nucleus and in cytoplasma of the cancerous cells. In particular, non-uniform distribution of nucleous chromatin, its quantitative decrease, enlargement of nucleoli, destruction of the cytoplasmic network membranes, vacuolization of mitochondria with destruction of crista therein, were observed. Preoperative chemotherapy leads to distortion of the genetic information of cancerous cells, causes inhibition of energy and metabolism processes in these cells, which results in perish of the cells and in regression of tumours.