Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Laboratory evaluations in HIV-1-associated cognitive/motor complex

K Syndulko1, E J Singer, J Nogales-Gaete

  • 1Department of Neurology, University of California, Los Angeles School of Medicine.

The Psychiatric Clinics of North America
|March 1, 1994
PubMed
Summary

Currently, no single lab test definitively diagnoses or predicts HIV-1-associated cognitive/motor complex. Cerebrospinal fluid markers show promise for early detection and treatment monitoring of HIV-1 brain infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic impact of acute kidney injury on one-year survival in patients undergoing high-risk PCI with Impella support.

Scientific reports·2026
Same author

Tuberculosis after allogeneic hematopoietic stem cell transplantation: a decade nationwide case-control retrospective study in low-incidence country.

Bone marrow transplantation·2026
Same author

Cognition in People Aged 80 Years and Older: Determinants and Predictors of Change from a Population-Based Representative Study in Germany.

The Journal of frailty & aging·2023
Same author

Cerebral empyema and abscesses due to Cutibacterium acnes.

Medecine et maladies infectieuses·2019
Same author

A practical approach to tuberculosis diagnosis and treatment in liver transplant recipients in a low-prevalence area.

Medecine et maladies infectieuses·2018
Same author

Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Medical Diagnostics

Background:

  • Human Immunodeficiency Virus type 1 (HIV-1) can affect the central nervous system (CNS).
  • HIV-1-associated cognitive and motor complex is a clinical diagnosis, often made after other neurological conditions are excluded.
  • Current laboratory tests lack definitive diagnostic or prognostic markers for HIV-1 CNS disease.

Purpose of the Study:

  • To review the utility of laboratory tests in diagnosing and monitoring HIV-1 CNS effects.
  • To identify promising biomarkers for early detection and treatment evaluation of HIV-1 neurological complications.

Main Methods:

  • Review of current and emerging laboratory diagnostic procedures for HIV-1 CNS disease.
  • Analysis of Magnetic Resonance (MR) imaging, cerebrospinal fluid (CSF) examinations, and advanced neuroimaging techniques.

Related Experiment Videos

  • Evaluation of electrophysiologic methods and specific CSF biomarkers.

    • Main Results:

    • MR imaging and CT scans lack sensitivity for early HIV-1 CNS detection or monitoring disease progression.
    • Certain CSF variables, including quinolinic acid, p24 antigen, neopterin, beta 2m, and intrathecal IgG synthesis, show potential as early markers.
    • Advanced research tools like PET, SPECT, and electrophysiologic methods show promise but require further validation.

    Conclusions:

    • HIV-1-associated cognitive/motor complex remains a clinical diagnosis.
    • CSF markers and electrophysiologic methods are valuable adjuncts, providing presumptive evidence of CNS damage.
    • Longitudinal studies are needed to validate new diagnostic and prognostic markers for HIV-1 neurological disease.