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Human growth hormone

J S Strobl1, M J Thomas

  • 1Department of Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown.

Pharmacological Reviews
|March 1, 1994
PubMed
Summary
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Human growth hormone (hGH) impacts metabolism and has potential roles in sleep, reproduction, immunity, and aging. Future drug development may focus on stimulating the body's own hGH release.

Area of Science:

  • Endocrinology
  • Human Physiology

Background:

  • Human growth hormone (hGH) research spans over a century.
  • Initially recognized for its role in longitudinal growth, hGH is now understood to influence protein, lipid, and carbohydrate metabolism.

Purpose of the Study:

  • To review the multifaceted roles of hGH beyond growth.
  • To explore emerging areas of hGH research, including sleep, reproduction, immune function, mental well-being, and aging.
  • To discuss current therapeutic approaches and future directions in hGH treatment.

Main Methods:

  • Review of existing scientific literature on human growth hormone.
  • Analysis of the impact of recombinant DNA technology on hGH supply.
  • Examination of neuroendocrine regulation of hGH secretion.

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Main Results:

  • hGH has broad metabolic effects and potential roles in various physiological processes.
  • Recombinant DNA technology ensures a safe, abundant supply of hGH, though it is costly.
  • Pharmacological properties of administered hGH are suboptimal.

Conclusions:

  • Most growth hormone deficiency stems from secretion defects, not production issues.
  • Understanding neuroendocrine regulation enables drug development for stimulating endogenous hGH release.
  • Targeting endogenous hGH secretion represents a promising avenue for future therapeutic strategies.