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High-dose interstitial brachytherapy for glioblastoma multiforme
E Micheletti1, G Baroncelli, B La Face
1Radiotherapy Department, University-Hospital of Brescia, Italy.
Tumori
|February 28, 1994
Summary
High-dose rate brachytherapy offers a short treatment period for glioblastoma multiforme (GBL). This HDR brachytherapy approach showed potential for palliation, with some patients experiencing improved performance status post-treatment.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Glioblastoma multiforme (GBL) has a poor long-term survival prognosis.
- Conventional radiotherapy offers only temporary results for GBL treatment.
Purpose of the Study:
- To evaluate the therapeutic and psychologic effects of high-dose rate (HDR) brachytherapy for inoperable GBL.
- To assess the feasibility and outcomes of a novel HDR brachytherapy protocol for GBL palliation.
Main Methods:
- Five patients with GBL underwent stereotactic biopsy followed by HDR brachytherapy.
- A single coaxial after-loading catheter was stereotactically placed within the tumor.
- Treatment involved 5 fractions of 5 Gy/fraction, delivered in 2 sessions per day.
Main Results:
- The HDR brachytherapy protocol was well-tolerated by patients.
- Tumor progression recurred between 8 and 16 weeks post-treatment.
- Average survival was 21 weeks, with some patients showing initial performance status improvement.
Conclusions:
- HDR brachytherapy presents a viable option for GBL palliation due to its short treatment duration.
- Potential improvements include multi-catheter implants and a more fractionated treatment schedule.
- This approach offers advantages for managing GBL symptoms and improving patient well-being.