Cardiac paraprotein associated with Waldenstrom's macroglobulinemia: a case report
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Updated: Oct 9, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
Published on: April 7, 2015
1LDS Hospital Electron Microscopy Laboratory, Salt Lake City, Utah.
Abstract:
A case of myocardial paraprotein deposition in a patient with Waldenstrom's macroglobulinemia is presented. Routine light microscopy revealed diffuse widening of interstitial regions by pale eosinophilic material that had a grayish cast on trichrome stains and was Congo red negative. Immunofluorescence showed strong immunoglobulin M and kappa light chain staining around blood vessels but predominantly around myocytes. Ultrastructural examination revealed massive deposition of flocculent electron-dense material around myocytes and occasionally around blood vessels.
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