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Published on: July 19, 2007
Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma
Insights
Allergen immunotherapy with Dermatophagoides pteronyssinus tyrosine absorbate improved asthma control in children. Treated children required less medication while maintaining lung function, with late allergic reactions diminishing.
Area of Science:
- Allergy and Immunology
- Pediatric Pulmonology
Background:
- Asthma in children is often triggered by allergens like house dust mites.
- Bronchial sensitivity to Dermatophagoides pteronyssinus necessitates effective treatment strategies.
Purpose of the Study:
- To evaluate the efficacy of hyposensitisation using Dermatophagoides pteronyssinus tyrosine absorbate in asthmatic children.
- To assess the impact on medication use, lung function, and allergic responses.
Main Methods:
- A 12-month, double-blind, placebo-controlled clinical trial.
- Inclusion of children with bronchial sensitivity to Dermatophagoides pteronyssinus.
- Monitoring of clinical symptoms, lung function, and bronchial provocation tests.
Main Results:
- Hyposensitisation demonstrated effectiveness in improving asthma control.
- Treated children used significantly less medication compared to controls.
- Lung function was maintained, and late-phase allergic reactions to Dermatophagoides pteronyssinus were reduced in half of the improved patients.
Conclusions:
- Dermatophagoides pteronyssinus hyposensitisation is a viable treatment for pediatric asthma.
- The therapy reduces medication needs and improves clinical outcomes.
- Loss of late-phase reaction correlates with greatest symptom improvement.
Abstract:
Hyposensitisation with Dermatophagoides pteronyssinus tyrosine absorbate in asthmatic children with bronchial sensitivity to D. pteronyssinus was effective in a 12-month double-blind controlled clinical trial. Compared with controls, treated children used a smaller quantity of drugs while maintaining clinical and lung function improvements. In most children who improved there was no change in immediate response to D. pteronyssinus on bronchial provocation test, but the late reaction was lost in half the patients and these showed the greatest improvement in symptoms.
