Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Metronidazole hypersensitivity

S Knowles¹, T Choudhury, N H Shear

¹Department of Pharmacy, Sunnybrook Health Science Centre, North York, Ontario, Canada.

The Annals of Pharmacotherapy

|March 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Burden of Neonatal Late-Onset Sepsis.

Irish medical journal·2025

Same author

Peritonsillar Abscess at a Dedicated Otolaryngology Emergency Department.

Irish medical journal·2023

Same author

Vancomycin dosing in neonates and sub-therapeutic levels.

Irish medical journal·2023

Same author

Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus.

Orphanet journal of rare diseases·2023

Same author

Experimental Infection of Mexican Free-Tailed Bats (<i>Tadarida brasiliensis</i>) with SARS-CoV-2.

mSphere·2023

Same author

Bacteriological Profiles in Early-Onset-Sepsis (EOS) and Late-Onset-Sepsis (LOS) in Neonates.

Irish medical journal·2022

Same journal

Severe Phototoxic Skin Reaction Associated With Vandetanib: Implications for Pharmaceutical Care.

The Annals of pharmacotherapy·2026

Same journal

Efficacy and Safety of Oral PCSK9 Inhibitors in Adults With Hypercholesterolemia: An Updated Systematic Review and Meta-Analysis of RCTs.

The Annals of pharmacotherapy·2026

Same journal

RSVpreF: A Vaccine for the Respiratory Syncytial Virus.

The Annals of pharmacotherapy·2026

Same journal

Severe Acute Hepatitis Induced by Combined Rosuvastatin and Ticagrelor Therapy Post-PCI: The Challenges of Multi-Drug DILI Diagnosis.

The Annals of pharmacotherapy·2026

Same journal

Modified vs Full Lead-in Dose Apixaban and Rivaroxaban for Treatment of Acute Venous Thromboembolism.

The Annals of pharmacotherapy·2026

Same journal

A Comparison of Phenobarbital Dosing Strategies for the Treatment of Alcohol Withdrawal Syndrome.

The Annals of pharmacotherapy·2026

See all related articles

A patient experienced a severe hypersensitivity reaction to oral metronidazole, a rare event. Improved patient education and documentation could prevent such adverse drug reactions.

Area of Science:

Pharmacology
Dermatology
Infectious Diseases

Background:

Recurrent vaginitis is a common condition often treated with metronidazole.
Hypersensitivity reactions to metronidazole, though rare, can be severe.

Observation:

A patient with a history of vaginitis developed erythema to intravaginal metronidazole.
Upon oral metronidazole administration for bacterial vaginosis, she experienced chills, fever, rash, and erythema.
The patient's condition worsened with shortness of breath and edema, requiring systemic corticosteroids.

Findings:

The case suggests a possible severe hypersensitivity reaction to oral metronidazole.
Prompt treatment with antihistamines and corticosteroids led to patient improvement.
Alternative treatments for vaginitis were utilized.

Related Experiment Videos

Implications:

This case highlights the importance of thorough patient history and potential drug cross-reactivity.
Enhanced patient education, especially in native languages, may prevent severe adverse drug events.
Consideration of alternative therapies is crucial for patients with a history of metronidazole intolerance.