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Oncogenes and cell death

E A Harrington1, A Fanidi, G I Evan

  • 1Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK.

Current Opinion in Genetics & Development
|February 1, 1994
PubMed
Summary
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Oncogenes and tumor suppressor genes regulate programmed cell death (apoptosis). Dysregulation of these genes contributes to cancer development and drug resistance, impacting cell proliferation and death pathways.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Programmed cell death (apoptosis) is crucial for normal development and tissue homeostasis.
  • Aberrations in apoptotic pathways are implicated in various diseases, including cancer.
  • Oncogenes and tumor suppressor genes play significant roles in regulating cell survival and death.

Purpose of the Study:

  • To investigate the role of oncogenes and tumor suppressor genes in apoptosis.
  • To understand the implications of altered cell death pathways in carcinogenesis and drug resistance.
  • To explore the relationship between cell proliferation and cell death signaling.

Main Methods:

  • Analysis of gene expression data related to apoptosis.
  • Review of literature on oncogenes, tumor suppressor genes, and apoptosis.

Related Experiment Videos

  • Examination of signaling pathways involved in cell death regulation.

    • Main Results:

    • Deregulated expression of genes like bcl-2 and loss of p53 are linked to cancer.
    • Autocrine activation of anti-apoptotic pathways contributes to tumor progression.
    • Paradoxically, some oncogenes can induce apoptosis, suggesting complex regulatory mechanisms.

    Conclusions:

    • Lesions in the cell death pathway are critical in cancer development and drug resistance.
    • The interplay between cell proliferation and cell death pathways has significant implications for cancer models.
    • Targeting apoptotic pathways presents potential therapeutic strategies for cancer treatment.