Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The IRS-1 signaling system

M F White1

  • 1Research Division, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215.

Current Opinion in Genetics & Development
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Insulin receptor substrate 1 (IRS-1) is crucial for insulin signaling, mediating signals through tyrosine phosphorylation. Other growth factors and cytokines may also use this pathway, with more IRS-1-like molecules potentially undiscovered.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.

Diabetes, obesity & metabolism·2014
Same author

Chin augmentation: Subperiosteal and supraperiosteal implants.

Aesthetic plastic surgery·2013
Same author

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

Diabetologia·2012
Same author

The incidence of enterococci in human feces.

Journal of bacteriology·2010
Same author

Human IL6 enhances leptin action in mice.

Diabetologia·2009
Same author

Archaeal DNA repair: paradigms and puzzles.

Biochemical Society transactions·2003
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Endocrinology

Background:

  • Insulin receptor substrate 1 (IRS-1) is a key mediator of insulin receptor signaling.
  • IRS-1 undergoes multi-site tyrosine phosphorylation.
  • IRS-1 associates with Src homology 2 (SH2) domain-containing signaling molecules.

Purpose of the Study:

  • To elucidate the role of IRS-1 in insulin signaling.
  • To investigate the involvement of other growth factors and cytokines in the IRS-1 pathway.
  • To explore the existence of novel IRS-1-like adapter molecules.

Main Methods:

  • Tyrosine phosphorylation analysis of IRS-1.
  • Investigation of protein-protein interactions involving IRS-1.
  • Exploration of signaling pathways activated by growth factors and cytokines.

Related Experiment Videos

Main Results:

  • IRS-1 is a principal substrate of insulin receptor tyrosine kinase.
  • IRS-1 mediates insulin signals via association with SH2 domain-containing proteins.
  • Interleukin-4 (IL-4) also stimulates IRS-1 phosphorylation, suggesting broader pathway involvement.

Conclusions:

  • The IRS-1 signaling pathway is utilized by multiple receptors beyond the insulin receptor.
  • Additional growth factors and cytokines likely employ the IRS-1 pathway.
  • The discovery of IRS-1-like adapter molecules, such as IRS-2 (4PS), is anticipated.