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Monophasic action potentials: concepts to practical applications

S Yuan1, C Blomström-Lundqvist, S B Olsson

  • 1Department of Cardiology, University Hospital, Lund, Sweden.

Journal of Cardiovascular Electrophysiology
|March 1, 1994
PubMed
Summary
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Monophasic action potential (MAP) recordings accurately assess heart repolarization and activation times. This review details MAP techniques for clinical use in evaluating arrhythmias and drug effects.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Monophasic action potential (MAP) recordings offer accurate intracellular action potential repolarization and local activation time data.
  • The contact catheter technique has made in vivo MAP recording simpler and safer, establishing it as a preferred method for assessing myocardial repolarization.

Purpose of the Study:

  • To provide comprehensive information on the practical clinical applications of Monophasic Action Potential (MAP) recording.
  • To detail the technical aspects, clinical uses, and limitations of MAP recording in electrophysiology.

Main Methods:

  • MAPs are recorded endocardially using a contact catheter in electrophysiology labs.
  • Epicardial MAPs are obtained using electrode probes during open-heart surgery.
  • Technical aspects of MAP recording are described in detail.

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Main Results:

  • The review covers rate dependence of myocardial excitability and repolarization.
  • Effects of antiarrhythmic drugs on MAP duration and effective refractory period are discussed.
  • Applications in detecting ischemia, afterdepolarizations, triggered arrhythmias, repolarization dispersion, and mechanoelectric feedback are presented.

Conclusions:

  • MAP recording is a valuable clinical tool for understanding myocardial repolarization and arrhythmogenesis.
  • The review highlights the versatility of MAPs in various electrophysiological assessments and research.