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Granulocytic sarcoma showing chromosomal changes other than the t(8;21)
P Heimann1, E Vamos, A Ferster
1Department of Cytogenetics, Hôpital Universitaire Brugmann, Brussels, Belgium.
Cancer Genetics and Cytogenetics
|May 1, 1994
Abstract:
Cytogenetic analysis of a granulocytic sarcoma showed a 46,XX,der(X)t(X;1) (q28;q22), inv(3)(p21q27), inv(9)(p13q22),t(12;22)(p11;q11) karyotype. In addition, bone marrow aspirate disclosed the presence of cells with a 46,XX,inv(3)(p21q27),inv(9)(p13q22)(p11;q11) chromosomal pattern while the patient was clinically aleukemic. This case demonstrates that chromosomal abnormalities other than the classical t(8;21) can also be associated with granulocytic sarcoma.