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A primate model for chancroid

P A Totten1, W R Morton, G H Knitter

  • 1Department of Medicine, University of Washington, Seattle.

The Journal of Infectious Diseases
|June 1, 1994
PubMed
Summary
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Male pigtailed macaques (Macaca nemestrina) serve as a valuable primate model for chancroid, exhibiting lesions similar to human disease. This model aids future research into the pathogenesis of Haemophilus ducreyi infections.

Area of Science:

  • Primate Models
  • Infectious Diseases
  • Dermatology

Background:

  • Chancroid is a sexually transmitted infection caused by Haemophilus ducreyi.
  • Developing effective primate models is crucial for understanding chancroid pathogenesis and testing interventions.

Purpose of the Study:

  • To evaluate adult pigtailed macaques (Macaca nemestrina) as a potential primate model for chancroid.
  • To compare the induced disease in male and female macaques to human chancroid.

Main Methods:

  • Adult male (n=5) and female (n=4) pigtailed macaques were inoculated with Haemophilus ducreyi.
  • Lesion development, bacterial recovery, antibody response, and lymphadenopathy were monitored.

Main Results:

  • Male macaques developed ulcers resembling human chancroid lesions 6-12 days post-infection.

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  • Haemophilus ducreyi was recoverable from lesions up to 20 days.
  • Humoral antibodies were detected starting 1 week post-inoculation, and inguinal lymphadenopathy occurred in 4/5 males.
  • Female macaques did not develop comparable lesions.

    • Conclusions:

    • Experimental chancroid in adult male pigtailed macaques closely mimics human disease.
    • This primate model is suitable for future studies on chancroid pathogenesis and treatment.