Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Minimal change" multiple system atrophy

G K Wenning1, N Quinn, M Magalhăes

  • 1University Department of Clinical Neurology, Institute of Neurology, London, England.

Movement Disorders : Official Journal of the Movement Disorder Society
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global advances and future directions in lung cancer care: expert consensus and strategic priorities.

ESMO open·2026
Same author

The burden of Wilson's disease: Insights into clinical, psychological, and functional dimensions.

Rehabilitacion·2025
Same author

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure.

Annals of clinical and translational neurology·2025
Same author

Duvelisib with Docetaxel for Patients with Anti-PD-1 Refractory, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2024
Same author

The expression of <i>VDACs</i> and <i>Bcl2</i> family genes in pituitary adenomas: clinical correlations and postsurgical outcomes.

Frontiers in endocrinology·2024
Same author

The genetic landscape of mitochondrial diseases in the next-generation sequencing era: a Portuguese cohort study.

Frontiers in cell and developmental biology·2024
Same journal

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Comment on: "Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson's Disease".

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

A Phase 1 Study of Convection-Enhanced Delivery of Intraputaminal AAV2-GDNF in Advanced Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Reply to Comment on: "Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson's Disease".

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Alzheimer's Disease Cerebrospinal Fluid Biomarkers Predict Survival in Progressive Supranuclear Palsy.

Movement disorders : official journal of the Movement Disorder Society·2026
See all related articles

Glial cytoplasmic inclusions (GCIs) suggest multiple system atrophy (MSA) in atypical parkinsonism cases. Postmortem brain exams revealed GCIs even without typical cell loss, highlighting their diagnostic importance.

Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases

Background:

  • Atypical parkinsonism presents with symptoms overlapping Parkinson's disease but with distinct pathological features.
  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by autonomic dysfunction and parkinsonism.

Observation:

  • Two patients with atypical parkinsonism and autonomic failure were diagnosed with MSA.
  • Postmortem brain examination revealed significant cell loss limited to the substantia nigra and locus coeruleus.

Findings:

  • Glial cytoplasmic inclusions (GCIs) were identified in both cases, despite the restricted pattern of neuronal loss.
  • The presence of GCIs is proposed as a key pathological marker for MSA.

Implications:

Related Experiment Videos

  • GCIs are highly suggestive of a pathological MSA diagnosis, even when cell loss is confined to specific brainstem nuclei.
  • Routine examination of brains from atypical parkinsonism cases for GCIs is recommended for accurate pathological diagnosis.