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Osteomalacic myopathy

J A Russell1

  • 1Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts 01886.

Muscle & Nerve
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Osteomalacia can initially present as painful muscle weakness and brisk reflexes. Prompt diagnosis and treatment with a gluten-free diet and vitamin D can lead to significant recovery.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Neurology

Background:

  • Osteomalacia is a bone disorder characterized by inadequate mineralization.
  • It can manifest with musculoskeletal pain and weakness.
  • Vitamin D malabsorption is a common cause of osteomalacia.

Observation:

  • A 45-year-old woman presented with thigh pain and proximal muscle weakness.
  • Clinical examination revealed short stature, kyphoscoliosis, proximal weakness, and hyperreflexia.
  • Laboratory tests showed elevated alkaline phosphatase, hypophosphatemia, iron deficiency anemia, and hypocholesterolemia.

Findings:

  • The patient was diagnosed with osteomalacia.
  • Unrecognized gluten-sensitive enteropathy with vitamin D malabsorption was identified as the underlying cause.

Related Experiment Videos

  • Treatment with a gluten-free diet and vitamin D2 led to clinical improvement within 3 months.

    • Implications:

    • Proximal muscle weakness and hyperreflexia can be primary symptoms of osteomalacia.
    • Early diagnosis and management of osteomalacia are crucial for bone and muscle health.
    • This case highlights the importance of considering malabsorption syndromes in unexplained osteomalacia.