Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanism of intraocular pressure decrease after contact transscleral continuous-wave Nd:YAG laser

G J Liu1, A Mizukawa, S Okisaka

  • 1Department of Ophthalmology, National Defense Medical College, Saitama, Japan.

Ophthalmic Research
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effect of Venetoclax in the treatment of leukocyte elevation during induction of acute promyelocytic leukemia].

Zhonghua yi xue za zhi·2025
Same author

Indirubin prevents structural damage to chicken lungs and trachea caused by <i>Mycoplasma gallisepticum</i> infection through attenuating oxidative stress and apoptosis.

British poultry science·2025
Same author

[Opportunities and expectations brought by artificial intelligence assisted peripheral blood cell morphology examination].

Zhonghua yi xue za zhi·2024
Same author

[A case of 1q21.3q44 duplication and Xp22.33p11.3 deletion].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2023
Same author

[Comparison and application of postprandial and fasting blood lipid levels in 839 physical examinees in Beijing].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2021
Same author

[Relationship between periodontitis and glomerular filtration rate in non-diabetic Chinese elderly patients in Beijing community].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2021

Contact transscleral cyclophotocoagulation using a continuous-wave Nd:YAG laser effectively lowered intraocular pressure in monkeys. Pars plana coagulation provided longer-lasting IOP reduction compared to pars plicata coagulation.

Area of Science:

  • Ophthalmology
  • Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) laser applications
  • Glaucoma treatment research

Background:

  • Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma.
  • Transscleral cyclophotocoagulation is a therapeutic option for managing refractory glaucoma.
  • Understanding the precise mechanisms and regional effects of cyclophotocoagulation is crucial for optimizing treatment outcomes.

Purpose of the Study:

  • To compare the physiological and morphological effects of contact transscleral cyclophotocoagulation at the pars plicata versus pars plana regions.
  • To elucidate the mechanisms underlying IOP reduction following Nd:YAG laser treatment in different ciliary body locations.

Main Methods:

  • Twenty-two cynomolgus monkey eyes underwent contact transscleral Nd:YAG cyclophotocoagulation.

Related Experiment Videos

  • Coagulation was performed at the pars plicata (1.0 mm from limbus) or pars plana (3.0 mm from limbus).
  • Physiological IOP measurements and histopathological examinations with tracer particle perfusion were conducted up to 6 months post-treatment.

    • Main Results:

    • Pars plicata coagulation initially decreased IOP but returned to baseline by 8 weeks, associated with ciliary process atrophy.
    • Pars plana coagulation resulted in sustained IOP reduction throughout the 6-month observation period.
    • Histopathology revealed enlarged extracellular space and enhanced uveoscleral outflow in the pars plana group, and reduced aqueous secretion in the pars plicata group.

    Conclusions:

    • Pars plicata cyclophotocoagulation primarily reduces IOP by decreasing aqueous humor secretion.
    • Pars plana cyclophotocoagulation enhances uveoscleral outflow, leading to more sustained IOP reduction.
    • The location of Nd:YAG laser application significantly influences the mechanism and duration of IOP control.