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Related Experiment Videos

Sertraline intoxication in a child

C A Kaminski1, M S Robbins, R E Weibley

  • 1Department of Pharmacotherapy and Research, Tampa General Hospital, Florida.

Annals of Emergency Medicine
|June 1, 1994
PubMed
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Accidental ingestion of sertraline, an antidepressant, caused severe toxicity in a child. Symptoms included tachycardia, hypertension, hallucinations, coma, and hyperthermia, indicating a potential for serotonin syndrome.

Area of Science:

  • Pharmacology
  • Toxicology
  • Pediatrics

Background:

  • Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant.
  • Previous research suggested low toxicity for sertraline.

Observation:

  • A child experienced severe intoxication following accidental sertraline ingestion.
  • The patient presented with tachycardia, hypertension, hallucinations, coma, hyperthermia, tremors, and skin flushing.

Findings:

  • The clinical presentation was consistent with serotonin syndrome.
  • Severe adverse effects were observed despite prior suggestions of low toxicity.

Implications:

  • Clinicians should consider serotonin syndrome in cases of accidental antidepressant ingestion.

Related Experiment Videos

  • This case highlights the potential for severe toxicity with sertraline, even in pediatric accidental overdose scenarios.