Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucose transporter 2 (GLUT 2): expression in specific brain nuclei

C Leloup1, M Arluison, N Lepetit

  • 1Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Université Paris VII, France.

Brain Research
|February 28, 1994
PubMed
Summary

Brain glucose sensors may involve glucose transporter 2 (GLUT 2). This study found GLUT 2 in key brain areas, suggesting its role in regulating feeding behavior and glucose sensing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strategic discussion on funding and access to therapies targeting rare diseases in Spain: an expert consensus paper.

Orphanet journal of rare diseases·2023
Same author

Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats.

The journal of prevention of Alzheimer's disease·2022
Same author

Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2022
Same author

A gerophysiology perspective on healthy ageing.

Ageing research reviews·2021
Same author

Healthy Aging Biomarkers: The INSPIRE's Contribution.

The Journal of frailty & aging·2021
Same author

The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System.

The Journal of frailty & aging·2021

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Endocrinology

Background:

  • Neurons in the brain detect glucose concentration changes.
  • Glucose transporters are potential candidates for these 'glucose sensors'.

Purpose of the Study:

  • To investigate if glucose transporter 2 (GLUT 2) functions as a cerebral glucose sensor.
  • To determine the localization and distribution of GLUT 2 in the brain.

Main Methods:

  • Polymerase chain reaction (PCR) to detect GLUT 2 mRNA.
  • Immunocytochemistry and electron microscopy to visualize GLUT 2 protein distribution and cellular localization.

Main Results:

  • GLUT 2 mRNA was detected in specific brain nuclei, including those involved in feeding behavior.

Related Experiment Videos

  • GLUT 2 immunoreactivity was widespread in the brain, localized to astrocytes.
  • GLUT 2 was found in regions associated with feeding regulation.

    • Conclusions:

    • Glucose transporter 2 (GLUT 2) is present in the brain and localized to astrocytes.
    • The distribution of GLUT 2 in feeding-related brain regions supports its role in cerebral glucose sensing.