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[A case of chronic herpes encephalitis with myelodysplastic syndrome (MDS)]

M Ejima1, H Tanaka, M Ueda

  • 1Department of Neurology, Tokyo Women's Medical College.

Rinsho Shinkeigaku = Clinical Neurology
|March 1, 1994
PubMed

Insights

A 72-year-old male with myelodysplastic syndromes (MDS) experienced prolonged herpes simplex encephalitis. His condition improved with aciclovir, suggesting MDS-related immune suppression contributed to the atypical presentation.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Hematology

Background:

  • Myelodysplastic syndromes (MDS) can impair immune function.
  • Herpes simplex virus (HSV) typically causes acute central nervous system (CNS) infections.

Observation:

  • A 72-year-old male with MDS presented with progressive dementia, convulsions, and altered consciousness.
  • Brain imaging revealed abnormalities in the right temporal-parietal lobe.
  • Herpes simplex virus DNA was detected in cerebrospinal fluid (CSF).

Findings:

  • The patient was diagnosed with herpes simplex encephalitis, but the clinical course was prolonged and atypical.
  • Aciclovir treatment halted symptom progression.
  • Brain imaging showed persistent abnormalities for over four months.

Implications:

  • MDS-related immune compromise may lead to chronic or atypical herpes simplex encephalitis.
  • This case highlights the importance of considering underlying immune deficiencies in prolonged CNS infections.
  • Further research is needed to understand the interaction between MDS and CNS viral infections.

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