[The genesis of experimental granulosa cell tumors of the ovaries]

Ovaries and their tumors were investigated in virgin female mice (78 control and 252 experimental) of line A and CC57W (aged-from 1 to 1 1/2 months) in the experiments with intravaginal application of polyurethan, 7,12-dimethylbenz (a) anthracene, 8-oxychinoline, synoestrol. It was demonstrated that only granulosa elements of atresic follicles are involved in the process of blastomogenesis. Theca-tissue showed no appreciable participation in proliferative processes. Totally, pretumor changes were noted in 56 cases, folliculomas or pathological changes morphologically identical to microfolliculomas- in 26 cases.