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Tumor associated glycoprotein-72 is highly expressed in prostatic adenocarcinomas
R B Myers1, R F Meredith, J Schlom
1Department of Pathology, University of Alabama at Birmingham 35294-7331.
The Journal of Urology
|July 1, 1994
Summary
Tumor associated glycoprotein-72 (TAG-72) is frequently expressed in prostate cancer, unlike carcinoembryonic antigen (CEA). This finding highlights TAG-72 as a potential biomarker for prostatic adenocarcinoma detection.
Area of Science:
- Oncology
- Biomarkers
- Cancer Research
Background:
- Oncofetal antigens like TAG-72 and CEA are expressed during development and can reappear in cancer.
- Prostate cancer diagnosis and treatment can be improved by identifying specific tumor markers.
Purpose of the Study:
- To investigate the expression of TAG-72 and CEA in malignant prostatic tissues.
- To compare the sensitivity of different monoclonal antibodies for detecting TAG-72.
Main Methods:
- Immunohistochemical analysis of prostatectomy specimens.
- Utilized monoclonal antibodies B72.3, CC49, and CC83 for TAG-72 detection.
- Used COL-1 antibody for CEA detection.
Main Results:
- TAG-72 was detected in 63% of malignant specimens with B72.3 and approximately 80% with CC49 or CC83.
- TAG-72 expression was primarily cytoplasmic and luminal within malignant cells.
- CEA was not detected in malignant prostatic tissues using the COL-1 antibody.
Conclusions:
- TAG-72 is frequently expressed in prostatic adenocarcinomas.
- TAG-72 shows promise as a biomarker for prostate cancer.
- CEA is not a reliable marker for prostatic adenocarcinoma in this study.
