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[Bronchial hyperreactivity other than that seen in asthma]
1Hôpital Bichat, INSERM U 226, Faculté Xavier-Bichat, Paris.
Revue Des Maladies Respiratoires
|January 1, 1994
Summary
Bronchial hyper-responsiveness is not exclusive to asthma, appearing in allergic rhinitis and chronic lung diseases. This heightened airway response can impact lung function and disease progression.
Area of Science:
- Pulmonology
- Immunology
Context:
- Bronchial hyper-responsiveness (BHR) is commonly linked to asthma.
- However, BHR is increasingly recognized in various clinical settings beyond asthma.
Purpose:
- To explore the presence and implications of BHR in conditions other than asthma.
- To differentiate BHR mechanisms across different respiratory diseases.
Summary:
- Patients with allergic rhinitis frequently exhibit BHR, potentially contributing to chronic airway obstruction.
- BHR in chronic airflow limitation may differ from asthma and correlate with obstruction severity, complicating asthma diagnosis.
- Preliminary data suggest minimal BHR in interstitial lung disease, while lung transplant recipients may develop mild BHR due to cholinergic denervation.
- Viral infections can induce BHR in both asthmatics and non-asthmatics, highlighting virus-induced airway inflammation's role.
Impact:
- Understanding BHR in diverse conditions is crucial for accurate diagnosis and management of airway diseases.
- This knowledge may lead to targeted therapies for BHR-related complications in non-asthmatic conditions.
- Further research is needed to clarify BHR's role in interstitial lung disease and post-transplant scenarios.