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Pronounced bronchial hyper-responsiveness and asthma severity

P Plaschke1, B Bake

  • 1Asthma and Allergy Research Centre, Sahlgren's Hospital, University of Göteborg, Sweden.

Clinical Physiology (Oxford, England)
|March 1, 1994
PubMed
Summary

Pronounced bronchial hyper-responsiveness in asthma patients does not correlate with disease severity. A simplified bronchial hyper-responsiveness test is not useful for identifying severe asthma cases.

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Respiratory Medicine

Background:

  • Asthma severity assessment is crucial for patient management.
  • Bronchial hyper-responsiveness (BHR) is a hallmark of asthma.
  • The clinical significance of BHR in relation to asthma severity requires further investigation.

Purpose of the Study:

  • To evaluate the association between pronounced bronchial hyper-responsiveness and clinical asthma severity.
  • To determine if a simplified BHR test can identify patients with severe asthma.

Main Methods:

  • Fifty-six asthma patients underwent bronchial provocation testing with methacholine chloride at low concentrations.
  • Asthma severity was retrospectively and prospectively assessed using treatment intensity, hospitalization, intensive care unit (ICU) admissions, emergency visits, and sick leave days.

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  • Only inhaled bronchodilators were withheld prior to testing.

    • Main Results:

    • Pronounced bronchial hyper-responsiveness was observed in 28 out of 56 patients.
    • No significant association was found between pronounced bronchial hyper-responsiveness and the assessed measures of asthma severity.
    • The simplified BHR test did not differentiate patients with clinically severe asthma.

    Conclusions:

    • Pronounced bronchial hyper-responsiveness is not a reliable indicator of asthma severity in a clinical setting.
    • A single, simplified bronchial hyper-responsiveness test, without considering disease status or medication, is insufficient for identifying patients with severe asthma or predicting a poor prognosis.