Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MANEC TUMOR OF RECTUM. A RARE CASE SERIES OF 3 PATIENTS AND A LITERATURE REVIEW.

Experimental oncology·2024

Same author

Temporal differences and commonalities between hand and tool neural processing.

Scientific reports·2023

Same author

Dupilumab in pediatric severe chronic rhinosinusitis with nasal polyps and asthma.

European annals of otorhinolaryngology, head and neck diseases·2023

Same author

Sensitization to bee venom in Portuguese non-allergic beekeepers.

European annals of allergy and clinical immunology·2021

Same author

Hymenoptera Venom Allergy: Re-Sting reactions.

European annals of allergy and clinical immunology·2020

Same author

Exploring a rare case of occupational senna allergy.

Occupational medicine (Oxford, England)·2018

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Placenta, transcortin, and localized immune response

S Werthamer, S Govindaraj, L Amaral

The Journal of Clinical Investigation

|April 1, 1976

Summary

Researchers identified a placental protein similar to plasma transcortin. This protein may inhibit the maternal immune response to the fetus, preventing rejection during pregnancy.

Area of Science:

Immunology
Biochemistry
Reproductive Biology

Background:

The human placenta possesses unique proteins crucial for pregnancy maintenance.
Transcortin, a plasma protein, binds cortisol and plays a role in regulating its levels.
The presence and function of transcortin-like proteins within the placenta are not fully understood.

Purpose of the Study:

To identify and characterize a transcortin-like protein in human placental syncytiotrophoblastic cells.
To compare the biochemical and functional properties of placental transcortin with plasma transcortin.
To investigate the potential role of placental transcortin in modulating maternal immune responses.

Main Methods:

Purification of a cytoplasmic protein from human placenta using methods similar to plasma transcortin purification.

More Related Videos

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Related Experiment Videos

Last Updated: Jun 23, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Antigenic and biochemical characterization of the purified placental protein.

Assessment of cortisol binding affinity and inhibition of phytohemagglutinin response in maternal lymphocytes.

Main Results:

A cytoplasmic protein with antigenic and biochemical similarity to plasma transcortin was purified from human placenta.
Placental transcortin demonstrated a smaller sedimentation coefficient (3S vs 3.75S) and weaker cortisol binding compared to plasma transcortin.
The purified placental transcortin exhibited a greater ability to block the phytohemagglutinin response of maternal lymphocytes than serum transcortin.

Conclusions:

A distinct transcortin-like protein exists in human placental syncytiotrophoblast.
This placental transcortin may play a role in immune tolerance during pregnancy.
It is hypothesized that placental transcortin inhibits maternal cell-mediated immunity against the antigenic fetus.