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Collagen-based drug delivery and artificial tears
H E Kaufman1, T L Steinemann, E Lehman
1LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Journal of Ocular Pharmacology
|January 1, 1994
Summary
New collagen-based delivery systems, Collasomes and Lacrisomes, offer improved drug and lubricant delivery to the eye. These systems simplify application and reduce blurred vision for chronic ocular therapies.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Traditional collagen shields for chronic ocular therapy present challenges with insertion and blurred vision.
- A novel collagen-based delivery system is needed to improve patient compliance and therapeutic outcomes.
Purpose of the Study:
- To develop and evaluate a new collagen-based drug delivery system for ocular applications.
- To assess the efficacy and patient acceptance of this novel system for conditions like dry eye.
Main Methods:
- Development of collagen pieces (Collasomes) suspended in a viscous vehicle for easy instillation.
- Formulation of Lacrisomes with lipids for dry eye treatment.
- In vivo studies using sodium fluorescein to measure drug concentrations in ocular tissues.
- A preliminary controlled study comparing Lacrisomes to a vehicle control in patients with keratoconjunctivitis sicca (KCS).
Main Results:
- Collasomes demonstrated significantly higher concentrations of fluorescein in the cornea (17-42x) and aqueous humor (6-8x) compared to vehicle alone.
- In KCS patients, 76% preferred Lacrisomes over the vehicle control due to soothing effects and longer comfort.
- All tested preparations were well tolerated by study subjects.
Conclusions:
- The novel collagen delivery system (Collasomes/Lacrisomes) offers a promising alternative for chronic ocular drug delivery, simplifying application and enhancing drug penetration.
- Lacrisomes show potential for treating dry eye disease, improving patient comfort and satisfaction.
- Ongoing research focuses on optimizing collagen modification and formulation for enhanced drug diffusion control and patient comfort.