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Aging and parathyroid hormone secretion

T Fujita, M Ohata, K Ota

    Journal of Gerontology
    |September 1, 1976
    PubMed
    Summary
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    Aging in rats significantly reduces parathyroid hormone (PTH) secretion. Both in vitro and in vivo studies show diminished PTH release in older rats, indicating a decline in endocrine function with age.

    Area of Science:

    • Endocrinology
    • Gerontology
    • Physiology

    Background:

    • Parathyroid hormone (PTH) plays a critical role in calcium homeostasis.
    • Age-related changes in endocrine function are common but not fully understood for all hormones.

    Purpose of the Study:

    • To investigate the influence of aging on parathyroid hormone secretion and release in rats.
    • To compare PTH secretion in young versus aged rats under basal and stimulated conditions.

    Main Methods:

    • In vitro study using cultured rat parathyroid glands from young (1-mo-old) and aged (18-mo-old) rats.
    • In vivo study involving EDTA injection to induce hypocalcemia in rats of different ages.
    • Quantification of parathyroid hormone (PTH) using radioimmunoassay (RIA).

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    Main Results:

    • Parathyroid glands from 18-mo-old rats released significantly less PTH compared to 1-mo-old rats across various calcium concentrations in vitro.
    • In vivo, older rats exhibited a reduced PTH secretion response to EDTA-induced hypocalcemia, shown by lower deltaPTH/deltaCa values.
    • These findings indicate a decrease in PTH secretion with advancing age in rats.

    Conclusions:

    • Parathyroid hormone secretion and release capacity diminish with age in rats.
    • Aging appears to impair the parathyroid glands' ability to respond to hypocalcemic stimuli.
    • This age-related decline in PTH function may have implications for calcium metabolism in older animals.