[Influence of long-term hemodialysis on serum trace elements concentration in patients with chronic renal failure]

52 patients with chronic renal failure treated by haemodialysis and 21 healthy subjects were observed. All patients were divided into 3 groups: patients treated by 1-50 months haemodialysis (group A), patients treated by 51-100 months haemodialysis (group B), patients treated by 100 months (group C). The blood samples of all patients were withdrawn for the estimation of creatinine, haemoglobin concentration, haematocrit value and zinc, copper, selenium and nickel concentrations immediately before and after dialysis. In healthy subjects only one estimation was provided. In all patients serum zinc, selenium and nickel concentrations were significantly lower than in healthy subjects. Copper concentration was insignificantly higher in normals than in patients with CRF. No significant difference in serum concentration of zinc copper, selenium and nickel between long term (group C) and short term (group A and B) haemodialysis patients was detected. During haemodialysis the decrease of serum zinc, copper and selenium levels was observed in all examined groups.

1. Serum zinc, selenium and nickel concentrations were significantly lower in patients treated by haemodialysis than in healthy subjects. 2. During haemodialysis the serum concentrations of zinc, copper and selenium were decreased. 3. Serum zinc, copper, selenium and nickel concentrations were the same in long and short term haemodialysed patients.