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[Diarrhea]

E Schmidt-Hengst1, W Sauer, C Schmidt

  • 1Medizinische Poliklinik, Universität Bonn.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|September 14, 1993
PubMed
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Nonsteroidal anti-inflammatory drug (NSAID) use caused a gastric ulcer, leading to a gastrocolic fistula and colitis. Surgical intervention involving gastric and colon resection resolved the patient's symptoms.

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Surgical Oncology

Background:

  • Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to serious gastrointestinal complications.
  • Gastric ulceration is a known side effect of NSAID therapy.
  • Fistula formation is a rare but severe complication of untreated peptic ulcer disease.

Observation:

  • A 50-year-old female presented with a two-week history of watery diarrhea.
  • The patient had a history of chronic back pain treated with NSAIDs for several months.
  • Endoscopic and radiologic investigations revealed a large gastrocolic fistula and transverse colon colitis.

Findings:

  • The gastrocolic fistula was attributed to NSAID-induced gastric ulceration.
  • Acid-induced colitis was identified in the transverse colon.

Related Experiment Videos

  • The patient's symptoms were directly linked to the gastrocolic fistula and colitis.

    • Implications:

    • Early recognition of NSAID-induced gastrointestinal complications is crucial for timely intervention.
    • Surgical management, including gastric and bowel resection, can effectively treat complex fistulas and associated colitis.
    • This case highlights the importance of considering NSAID toxicity in patients presenting with severe gastrointestinal symptoms and a history of chronic pain management.