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Related Experiment Videos

Erythrocyte sedimentation rate in elderly blacks

F C Bester1, D J Weich, P N Badenhorst

  • 1Department of Internal Medicine, University of the Orange Free State, Bloemfontein.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|July 1, 1993
PubMed
Summary

This study established new reference ranges for erythrocyte sedimentation rate (ESR) in elderly Black individuals. The findings suggest ESR

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Area of Science:

  • Gerontology
  • Clinical Chemistry
  • Hematology

Background:

  • Erythrocyte sedimentation rate (ESR) is a common hematological test.
  • Establishing accurate reference ranges for specific populations, like the elderly, is crucial for diagnostic interpretation.
  • Previous studies may not adequately represent the elderly Black population in the Orange Free State.

Purpose of the Study:

  • To determine age- and sex-specific reference ranges for ESR in an elderly Black population.
  • To evaluate the diagnostic utility of ESR in this demographic, using C-reactive protein (CRP) as a benchmark.
  • To provide updated reference values for clinical use in geriatric patients.

Main Methods:

  • Random community sampling of elderly Black individuals in the Orange Free State.

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  • ESR measurements performed using the standardized Westergren method.
  • Serum analysis included total protein, albumin, immunoglobulin, and C-reactive protein (CRP) levels.
  • Non-parametric statistical analyses were employed for data interpretation.

    • Main Results:

    • For elderly Black men with normal CRP and immunoglobulin levels, 99% of ESR values were below 44 mm/h.
    • For elderly Black women with normal CRP and immunoglobulin levels, 99% of ESR values were below 62 mm/h.
    • Using CRP as the gold standard, ESR sensitivity was 33% for men and 75% for women, with specificities of 91% and 89%, respectively.

    Conclusions:

    • The study provides specific ESR reference ranges for elderly Black men (44 mm/h) and women (62 mm/h).
    • ESR demonstrates moderate sensitivity but high specificity in identifying inflammation in this population when compared to CRP.
    • These findings aid in the accurate interpretation of ESR results in elderly Black patients.