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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[Physiological valvular regurgitation in healthy persons (its prevalence, hemodynamic characteristics and
Abstract:
Two-dimensional Doppler echocardiography (DECG) was employed to examine for valvular regurgitation 100 healthy subjects. Physiological valvular regurgitation (PVR) was detected in 32 of them. It was defined as isolated pulmonary, isolated tricuspid, combined tricuspid and pulmonary, mitral in 17%, 9%, 4% and 2% of the examinees, respectively. Hemodynamically, PVR was characterized by low maximal speed of the flow and minimal extension. It should be noted that similar hemodynamic DECG parameters can be registered in minimal aphonic valvular regurgitation arising in latent rheumatic and viral endocarditides. This fact must be taken into consideration when making the differential diagnosis.
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