Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methyl methacrylate: inhalation developmental toxicity study in rats

H M Solomon1, J E McLaughlin, R E Swenson

  • 1Rohm and Haas Company, Spring House, Pennsylvania 19477.

Teratology
|August 1, 1993
PubMed
Summary

Methyl methacrylate vapor inhalation did not cause fetal toxicity or malformations in rats, even at maternally toxic doses. This study indicates a lack of developmental toxicity for methyl methacrylate.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Qualitative evaluation of postdoctoral trainee and faculty advisor experiences within a research-intensive school of pharmacy.

BMC medical education·2022
Same author

Shelf Life and Toxin Development by Clostridium botulinum during Storage of Modified-Atmosphere- Packaged Fresh Aquacultured Salmon Fillets.

Journal of food protection·2019
Same author

Effect of Low Temperatures on Growth of Nonproteolytic Clostridium botulinum Types B and F and Proteolytic Type G in Crabmeat and Broth <sup>1</sup>.

Journal of food protection·2019
Same author

Evaluation of the Botulism Hazard from Nitrogen-Packed Sandwiches.

Journal of food protection·2019
Same author

Toxin Production by Clostridium botulinum in Shelf-Stable Pasteurized Process Cheese Spreads.

Journal of food protection·2019
Same author

Sporulation and Toxin Production by Clostridium botulinum Type G.

Journal of food protection·2019

Area of Science:

  • Toxicology
  • Developmental Biology
  • Reproductive Toxicology

Background:

  • Methyl methacrylate is a widely used industrial chemical.
  • Understanding its potential reproductive and developmental risks is crucial for occupational safety.

Purpose of the Study:

  • To evaluate the developmental toxicity of methyl methacrylate following vapor inhalation exposure in pregnant rats.
  • To determine if methyl methacrylate causes embryo-fetal toxicity or malformations at exposure levels causing maternal toxicity.

Main Methods:

  • Pregnant rats (Crl:CD) were exposed to methyl methacrylate vapor (0, 99, 304, 1,178, 2,028 ppm) for 6 hr/day on gestation days 6-15.
  • Maternal parameters (body weight, feed consumption, clinical signs) were monitored. Uterine and fetal parameters (corpora lutea, implantations, resorptions, fetal weight, external, skeletal, and visceral alterations) were assessed on day 20 of gestation.

Related Experiment Videos

Main Results:

  • Maternal toxicity, including transient body weight and feed consumption decreases, was observed at all exposure levels.
  • No treatment-related deaths occurred. No significant changes in reproductive parameters (corpora lutea, implantations, resorptions, litter size, sex ratio) were noted.
  • Fetal body weights were similar across groups. No treatment-related increases in external, visceral, or skeletal malformations or developmental variations were observed.

Conclusions:

  • Methyl methacrylate vapor inhalation up to 2,028 ppm did not induce embryo-fetal toxicity or malformations in rats.
  • Developmental toxicity was not observed even at exposure levels that caused maternal toxicity, suggesting a low risk for developmental effects.