Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antisense DNA]

Y Shoji1, J Shimada, Y Mizushima

  • 1Institute of Medical Science, St. Marianna University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Antisense DNA offers therapeutic potential but faces challenges like instability and poor cell entry. First-generation oligonucleotide analogues show promise in overcoming these issues for drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gradient-index microlens formed by ion-beam sputtering.

Applied optics·2010
Same author

Graded-index sphere lens with hemispherical rod cladding.

Applied optics·2010
Same author

Cladded radially inhomogeneous sphere lenses.

Applied optics·2010
Same author

Spectroscopic small loss measurements on infrared transparent materials.

Applied optics·2010
Same author

Design of gradient-index spherical lenses for optical pickup systems.

Applied optics·2010
Same author

Electrically accessible Lippmann hologram memory.

Applied optics·2010
Same journal

[A Case of Pulmonary Epithelioid Hemangioendothelioma Associated with Multiple Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Long-Term Survival in Three Cases with Pulmonary Metastases from Colorectal Cancer Given Low-Dose S-1 Under a Regimen Combining a Carbohydrate-Restricted Ketogenic Diet, Metformin, Vitamin D, Eicosapentaenoic Acid, and Other Complementary Therapies].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Preventive Effect of Saline Eye Wash for Eye Symptoms Due to High-Dose and Intermediate-Dose Cytarabine Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Examination of Factors Affecting the Efficacy of Naldemedine Tosilate Tablets for Opioid-Induced Constipation].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Recent Advances in the Treatment of HER2-Altered Solid Tumors].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[BRAF-Mutant Solid Tumor].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
See all related articles

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Context:

  • Antisense DNA is a promising therapeutic agent.
  • Challenges include biological instability and low membrane permeability.
  • First-generation oligonucleotide analogues have been developed to address these limitations.

Purpose:

  • To review the intracellular delivery of oligonucleotides.
  • To discuss overcoming delivery challenges for therapeutic applications.
  • To provide a pharmaceutical perspective on oligonucleotide delivery.

Summary:

  • Antisense DNA, a potential therapeutic, suffers from instability and poor cell membrane penetration.
  • Newly synthesized oligonucleotide analogues demonstrate promising in vitro and in vivo efficacy.

Related Experiment Videos

  • This review focuses on the pharmaceutical aspects of intracellular oligonucleotide delivery.

    • Impact:

    • Facilitates the development of novel nucleic acid-based therapies.
    • Improves understanding of oligonucleotide delivery mechanisms.
    • Enables more effective therapeutic strategies using antisense DNA.