Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Left ventricular hypertrophy: molecular aspects]

K Schwartz1, C Chassagne, L Carrier

  • 1INSERM Unité 127, hôpital Lariboisière, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlates of HIV-1 control after combination immunotherapy.

Nature·2025
Same author

Combination immunotherapy induces post-intervention control of HIV.

Research square·2025
Same author

Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis).

Journal of medical primatology·2023
Same author

Caregiving burden among informal caregivers of African American cancer survivors.

Journal of cancer survivorship : research and practice·2020
Same author

Porcine Reproductive and Respiratory Syndrome virus reduces feed efficiency, digestibility, and lean tissue accretion in grow-finish pigs.

Translational animal science·2020
Same author

Preparation and characterization of inorganic radioactive holmium-166 microspheres for internal radionuclide therapy.

Materials science & engineering. C, Materials for biological applications·2019
Same journal

Radiokymographic study of the kinetics of the middle arc and the hils in the normal subject.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

A medication for angina pectoris and pre-fibrillatory conditions; 1262 F; six years of clinical experience; action mechanism.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Circulatory changes following the injection of hypertonic saline solutions; application to the study of angina pectoris.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Alterations in coronary circulation during aortic insufficiency in young subjects.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Cardio-esophageal auscultation.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Hypertensive accidents following the injection of acetylcholine.

Archives des maladies du coeur et des vaisseaux·2010
See all related articles

Gene expression changes in left ventricular hypertrophy involve altered regulation of myosin and actin genes. Understanding these transcriptional changes is key to comprehending cardiac hypertrophy and failure.

Area of Science:

  • Molecular biology
  • Cardiovascular science
  • Gene regulation

Context:

  • Left ventricular hypertrophy (LVH) involves complex alterations in cardiac gene expression.
  • Mechanogenic transduction describes how mechanical forces influence gene expression in the heart.
  • Differential expression of myosin and actin multigenic families contributes to LVH pathology.

Purpose:

  • To elucidate the mechanisms of gene expression changes during left ventricular hypertrophy.
  • To investigate the role of transcriptional regulation in cardiac hypertrophy.
  • To understand the uncoordinated changes in contractile protein isoforms.

Summary:

  • Gene expression is altered during left ventricular hypertrophy through mechanogenic transduction.
  • This involves differential and uncoordinated changes in the expression of myosin and actin gene families.

Related Experiment Videos

  • The underlying genes are normal, but their regulation, primarily at the transcription stage, is disturbed.

    • Impact:

    • Provides insights into the pathogenesis of cardiac hypertrophy and heart failure.
    • Highlights the importance of understanding transcriptional regulation in cardiovascular disease.
    • Lays the groundwork for future research into therapeutic targets for cardiac dysfunction.